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A repeated-measures two-way ANOVA revealed a significant main effect of the factors treatment (F (1,16) = 12.47, P = 0.0028), time (days) (F (5,80) = 4.437, P = 0.0012), and a significant treatment time interaction (F (5,80) = 10.89, P 0.05

[3] Sublingual and nasal preparations are available but are not routinely recommended within UK clinical guidance and may not be licensed as medicines

In the face of vitamin B 12 deficiency, conversion of methylmalonyl-CoA to succinyl-CoA cannot take place, which results in accumulation of methylmalonyl-CoA and aberrant fatty acid synthesis