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5-amino-1MQ did not inhibit SIRT1 concentrations ranging from 10 nM 300 M, and minor reduction in SIRT1 activity was observed with 600 M 5-amino-1MQ (Figure 4E)

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Decreased levels of TNF- and IL-6 indicate that NNMT inhibition not only modulates metabolism but also improves the inflammatory microenvironment, a key component in metabolic disease development and insulin resistance

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