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A randomized controlled trial found that oral supplementation with 1,200 mg/day of lipoic acid for 10 weeks was of no benefit in treating HIV-associated cognitive impairment (103)

Mitochondrial theory of aging maturesroles of mtDNA mutation and oxidative stress in human aging

Social Withdrawal and Anhedonia Social withdrawal, modeled by ketamine 8 mg/kg over three days inducing social isolation, was completely antagonized by BPC-157 independently of locomotor effects

3.7 Correlation analysis between dominant fecal microbiota and cognitive deficit-related factors To further elucidate potential gut microbiota and brain interactions, correlations between the dominant fecal microbiota and cognitive factors were analyzed and visualized as a heatmap (Figure 8)

For longevity, the gut connection is particularly relevant