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Activation of UCP1, a proton channel in the inner mitochondrial membrane of brown adipocytes, produces a leak in the mitochondrial membrane and uncouples ATP synthesis from respiration, thereby dissipating energy as heat (6, 100)

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JAMA Network Open full text iconFULL TEXTcontents iconCONTENTSfigure iconFIGURES / TABLESattach iconSUPPLEMENTAL CONTENTreferences iconREFERENCESrelated iconRELATEDcomments iconCOMMENTS Download PDF Comment Top of Article Key Points Abstract Introduction Methods Results Discussion Conclusions Article Information References Figure 1

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Blood 132(Suppl

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note that MMA is not universally available on the NHS and can also be raised in renal impairment Homocysteine raised in both B12 and folate deficiency

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Worsening neurological symptoms : Progressive weakness, worsening balance problems, or deteriorating cognitive function despite treatment requires urgent assessment

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