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Extensive research has shown that overexpression of adhesion molecules, like VCAM-1 and ICAM-1, on the cerebral endothelium by recruiting circulating leukocytes into the inflammation areas has a crucial role in inflammation and progress of ischemic damage following acute stroke [60]

It should be noted that some case reports did not include complete clinical, treatment, and genetic data of patients

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MC1R activation through induction of UV radiationprotective skin pigmentation, increased DNA repair and control of aberrant cell growth may reduce the risk of melanoma but does not prevent the development of melanoma

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