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The contribution of the NLRP3 inflammasome has been largely demonstrated in fibrotic lung diseases, including silicosis [67,212,213,214] and cystic fibrosis [215,216], but the role of the NLRP3 inflammasome is increasingly discussed in the pathogenesis of COPD or asthma, too [208,217,218]

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(2003) Disturbed glutathione metabolism and decreased antioxidant levels in human immunodeficiency virus-infected patients during highly active antiretroviral therapypotential immunomodulatory effects of antioxidants

Although the microbial compositions of kefir vary significantly after fermentation with kefir grains, the core microbiome and metabolite profile are relatively consistent (120)

While these findings do not establish diagnostic biomarkers, they underscore the relevance of metabolic profiling in ASD and support further investigation into dietary strategies as adjunctive, individualized interventions