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Zn(ii)-Coordination-driven self-assembled nanoagents for multimodal imaging-guided photothermal/gene synergistic therapy

In the near future, we are likely to see increasingly sophisticated preclinical models of irAEs, risk stratification with irAE biomarkers, and evidence based approaches for the management of irAE subsets such as steroid-refractory disease (Fig

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GSH depletion does not induce mitochondrial superoxide or alter mitochondrial mass in RPE cells It has been suggested that mitochondria are predominant source of ROS upon H 2 O 2 -induced oxidative stress 7