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Dose-by-dose weight loss in Phase 2 (NEJM) Phase 2 NEJM weight loss by dose, 24 and 48 weeks Dose 1 mg 24 weeks -7.2% 48 weeks -8.7% Dose 4 mg 24 weeks -12.9% 48 weeks -17.5% Dose 8 mg 24 weeks -15.7% 48 weeks -22.8% Dose 12 mg 24 weeks -17.5% 48 weeks -24.2% Dose Placebo 24 weeks -1.6% 48 weeks -2.1% Source: Jastreboff et al., NEJM 2023

Product Name: Epithalon Strength: 10mg Chemical Name: Synthetic Tetrapeptide Bioregulator (Epitalon) CAS Number: 307297-39-8 Molecular Formula: CHNO Molecular Weight: 390.35 g/mol Amino Acid Sequence: Ala-Glu-Asp-Gly Appearance: White to Off-White Lyophilized Powder Classification: Peptide Bioregulator Research Compound Purity: Verified by analytical testing prior to release Analytical Methods: HPLC, Mass Spectrometry (MS) Research areas commonly associated with this compound include: Cognitive Neurological & Sleep Research Store lyophilized material refrigerated at 28C for routine storage

Patients with prior abdominopelvic surgeries or trauma may have tissue adhesions, and manual therapy may promote better motility and digestive function

People on blood thinners bruise more easily and should mention it beforehand

Never share needles, syringes, or multi-dose vials with another person