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Recently, a mosaic VLP vaccine containing HA and NA antigens was shown to induce nAb and T cells that could recognize a broad range of seasonal influenza strains and could protect against lethal H1N1 and H3N2 challenge in mice [118]

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the secondary outcome variables include the serum concentration of vitamin B12 (in pg/ml), adherence to treatment, quality of life (EuroQoL-5D questionnaire), patient 3satisfaction and patient preferences

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