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Gender differences in metformin effect on aging, life span and spontaneous tumorigenesis in 129/Sv mice

doi: 10.1007/s00784-018-2377-2 69 KimYLeeSKimSJangHHwangIJinSet al

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10.1016/j.psyneuen.2017.10.005 66

The classically activated macrophages M1 are in contact with high levels of Th1 cytokines (IFN-, IL-2, IL-12), proinflammatory cytokines (TNF, IL-1, IL-6, IL-18) and chemokines (MIP-1, MIP-1, RANTES) that favor the formation of viral reservoirs with strongly increased viral transcription and inhibition of HIV-1 entry to block superinfection within infected macrophages