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This is, then, oxidized by cytosolic isocitrate dehydrogenase 1 (IDH1) to -ketoglutarate with the production of NADPH required for the detoxification from reactive oxygen species (ROS

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Glycine Encephalopathy Deficiencies in the H, P, or T proteins of glycine decarboxylase result in glycine encephalopathy (GCE) which is characterized by nonketotic hyperglycinemia (NKH)

[DOI] [PubMed] [Google Scholar] 30.Taylor K.E., van den Berg C.W