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Additionally, during early embryonic development, the methylation profile of the GAD1 gene becomes irregular, suggesting that epigenetic regulation may already be impaired during critical periods of neural development (40).Studies have shown that reduced expression of GAD65 or GAD67 in the central nervous system (CNS) can lead to ASD-like symptoms in mice

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Lipid peroxidation induced by oxidative stress leads to DNA damage and ultimately brain cell death (Mochizuki, 2019)

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