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The bioavailability difference between routes means the same biological effect requires a higher oral dose than injectable but the mechanistic effects themselves translate across routes because the absorbed fraction reaches systemic circulation intact enough to engage the same downstream pathways

doi:10.1249/JSR.0000000000001264

9:e114774

[DOI] [PubMed] [Google Scholar] Cobb MH, Heagy W, Danner J, Lenhoff HM, Marshall GR

In recent years, plenty of reports have suggested that targeting the ferroptosis of renal cells may provide a highly available strategy for treating patients with kidney diseases
