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424 Another observational study that included data from 56,553 atrial fibrillation patients treated with DOACs found risks of mortality and stroke were lower in patients treated with rivaroxaban compared with apixaban, while the risks of embolic events other than stroke were similar

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These include: Nausea, vomiting, and diarrhoea (very common, especially during dose escalation) Reduced appetite and abdominal discomfort Constipation Risk of hypoglycaemia when used with insulin or sulphonylureas Pancreatitis and gallbladder disease have been reported Thyroid C-cell tumours have been observed in animal studies, though the relevance to humans is unknown Important safety considerations when using both treatments include: Mounjaro can reduce the effectiveness of oral contraceptives due to delayed gastric emptying