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One key frontier involves personalized nanotherapeutics that account for individual microbiome compositions, immune profiles, and wound pathophysiology

Global analysis of gene expression and Gene Set Enrichment Analysis (GSEA) in gastrocnemius muscle revealed that expression of pro-inflammatory cytokines and chemokines which are typically increased in obese state 22,25,26,27,28 such as chemokine (C-C motif) ligands 2, 6, 7, 9, 11 ( Ccl2 (Mcp1 ), Ccl6, Ccl7 (Mcp3 ), Ccl9, Ccl11 ) and chemokine (C-X-C motif) ligands 1, 9, 12 ( Cxcl1, Cxcl9, Cxcl12 ), and their receptors, IL6ra, Ccr1, Ccr2, Ccr3 , and Cxcr4 was not changed in muscle tissue of Cpt1b m/ mice compared to Cpt1b fl/fl mice (Supplementary Table S1)

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[DOI] [PubMed] [Google Scholar] 29.Orciuolo E., Stanzani M., Canestraro M., Galimberti S., Carulli G., Lewis R., Petrini M., Komanduri K.V

The protein concentration was measured by BCA kit (Thermo Scientific TM Pierce TM BCA Protein Assay Kit, Waltham, MA, United States)