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SASP factors include chemokines, cytokines, proteases, growth factors, and prostaglandin-related lipids that can negatively regulate neighboring cells

Notes on nomenclature: NAFLD and NASH correspond to MASLD and MASH, respectively, according to the current consensus

However, considering therapeutic strategies that target cancer cell metabolism alone is not sufficient because metabolic rewiring affects the composition, phenotype and function of cancer cells and microenvironmental components

Some studies find benefit to carnitine supplementation, while others find no significant benefit