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Targets 9 , 413418 (2008)

While the mutation of Cys151 to tryptophan, which mimics the reaction of Cys151 with inducers due to the bulky physical properties of the tryptophan side chain, is able to inhibit KEAP1s ubiquitin ligase function, the general applicability of these results to the wild-type protein is unclear, as C151W is a loss-of-function mutation (120, 134)

Instead, GGsTop had to be delivered thru the airway to inhibit this pool of GGT activity within the lung

Though it is not known what exactly causes vitiligo, low B12 can interfere with the manufacture of melanin and cause depigmentation in some people

& Melzack, R