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Why Cycling Matters Receptor desensitization occurs when constant peptide exposure downregulates receptor sensitivity

Nakatsuji T, Gallo RL

f) Primary cell cultures were seeded on chamber slides and fixed with 4% PFA for 15 min, then washed thrice with PBS

The results showed that Astragalus polysaccharide enhanced cell proliferation viability, promoted the expression of osteogenic marker gene proteins ALP and OC, upregulated the expression of osteoblast Bcl-2 anti-apoptotic proteins and p-AMPK and eNOS proteins, and downregulated the expression of Bax and cleaved caspase-3 pro-apoptotic proteins in a dose-dependent manner

doi: 10.3892/ol.2023.13852 61 NingYCuiYLiXCaoXChenAXuCet al