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p53 is one of the main factors that orchestrates apoptosis in response to DNA damage, and it controls the fate of hematopoietic cells deficient in both the Fanconi Anaemia ICL DNA repair pathway and the aldehyde-metabolizing enzyme Aldh2 in mice 13

These results may be approximated to Mirhadi et al

Sankaranarayanan et al

[DOI] [PMC free article] [PubMed] [Google Scholar] 13.Acetyl-L-carnitine activates the peroxisome proliferator-activated receptor- coactivators PGC-1/PGC-1-dependent signaling cascade of mitochondrial biogenesis and decreases the oxidized peroxiredoxins content in old rat liver

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