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For HCC, several therapies or drugs have been tried in the clinic, but no breakthroughs have been achieved, and even some approved drugs later failed to inhibit tumor growth due to the emergence of drug resistance mechanisms

Eight-fold increased risk for congenital heart defects in children carrying the nicotinamide N-methyltransferase polymorphism and exposed to medicines and low nicotinamide

Moreover, XH and its metabolites (isoxanthohumol, 8-prenylnaringenin, and 6-prenylnaringenin) have recently been analyzed by molecular docking to elucidate new potential anticancer targets

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The authors observed a striking similarity between diabetic and B 12 deficiency-induced neuropathy, while the staining patterns were different or absent in sural nerve biopsies from patients with other neuropathies (monoclonal gammopathy of unknown significance, CharcotMarieTooth disease, idiopathic peripheral neuropathy and alcohol abuse-induced neuropathy), indicating that the pathogenesis of these neuropathies may be different [41]