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This concept highlights the intricate, bidirectional communication among the gastrointestinal tract, the central nervous system (CNS), and the kidneys where dysfunction in one system can lead to cascading effects on the others (Yang et al., 2018)

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For example, NAD+-dependent enzymes include the sirtuins (SIRT1-7), a family of protein deacetylases involved in gene expression, stress responses, and metabolic regulation, as well as poly(ADP-ribose) polymerases (PARPs) that assist in DNA repair

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