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Oxidative stress in the RPE, induced by ROS such as hydrogen peroxide, is hypothesized to be an important driving force in the progression of this disease [16]

As mentioned above, Nrf2 is a protective factor for viral hepatitis, but it may contribute to the occurrence and progress of HCC

doi: 10.1016/j.jad.2011.06.005

Targeting NOX enzymes, especially NOX4, has shown promise in experimental models, and the dual NOX1/NOX4 inhibitor GKT137831 (setanaxib) has demonstrated anti-fibrotic efficacy in Phase II trials

To study the mutual interaction between physical exercise and antioxidant systems in rats, we selected swimming as a model for exercise performance