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The same study indicated that SRD5A2 could catalyze the hydride transfer from NADPH to finasteride, leading to the formation of a covalent bond between the nicotinamide C-4 atom of NADPH and the C-2 atom of finasteride 17 , which is highly consistent with our structural observation

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The Journal of Clinical Endocrinology & Metabolism, 107 (6), 1679-1685

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