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Acetly-coenzyme A is a substrate of acetylcholintransferase, whose activity is significantly reduced in people suffering from Alzheimer's disease

Interestingly, this physiologically relevant large mammalian animal model develops the three-layered valves and the MVP phenotype observed in these animals are close to what is described in humans, making this intermediary translational model of interest to study mechanisms associated with the disease (64)

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Studies of A kinetics in the presence of apoE suggests that apoE4 stabilizes soluble, cytotoxic, oligomeric A fragments and enhances fibrillogenesis [84]

The upper phase was transferred to a GC vial and dried overnight under vacuum at 4C