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Gitter, A

These interactions can trigger a series of immunoregulatory responses, involving both innate and adaptive immune systems and including cross-presentation of antigens, activation of CD 8 + T cells and CD 4 + T cells, phagocytosis, complement-mediated antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC)

By mapping how inflammatory pathways promote ferroptosis and how ferroptotic signals re-ignite inflammation, we can identify the leverage points to break the cycle (Figure 2)

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10.1073/pnas.1323599111 PNAS 63 KaminskiH.AndradeF