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Agranulocytosis is the most serious complication of antithyroid drug therapy and is estimated to occur in 0.1 to 0.5 percent of patients treated with these drugs [7]

Cyanocobalamin B12 contains a cyanide molecule that gives it stability in products and the body
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Therefore, HPLC gel filtration is recommended as a final polishing step that will isolate properly folded protein from aggregates or other contaminating species