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The structures of some isocereulides differed from that of cereulide by substitution of L- O -Val by L- O -Leu (isocereulide A), L-Val by L-Ala (isocereulide D), D-Ala by D-Ser (isocereulide C) and D- O -Leu by D- O -Val (isocereulide B), thus indicating a relaxed substrate specificity of the A domains and an inefficient proof reading by CesT 18

doi: 10.1158/1535-7163.MCT-20-0430

doi: 10.1111/dom.14863 [DOI] [PMC free article] [PubMed] [Google Scholar] 13.Perkovic V, Tuttle KR, Rossing P, Mahaffey KW, Mann JFE, Bakris G, Baeres FMM, Idorn T, Bosch-Traberg H, Lausvig NL, et al

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Signature effects of vector-guided systemic nano bioconjugate delivery across blood-brain barrier of normal, Alzheimers, and tumor mouse models