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Furthermore, a randomized human lens sample study involving 50 patients with unilateral/bilateral idiopathic immature senile cataracts showed that patients receiving vitamin E had higher levels of reduced GSH and GSH-Px as well as lower levels of MDA and lens opacity in the cortical cataractous lenses compared with the placebo group (69), directly confirming the protective effect of vitamin E in the human lens

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Additionally, targeting the RAGE cascade offers another approach to inhibit glycation-mediated pathology by blocking AGE-RAGE interactions and downstream signaling pathways associated with oxidative stress and inflammation

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