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Degradation Mechanism Avoided : The primary enemies of peptides are hydrolysis (breakdown by water) and oxidation (breakdown by oxygen)
The conservative approach involves cycling use (4-12 weeks on, 4-6 weeks off) to prevent potential receptor downregulation and maintain effectiveness
Abnormal redox status induced during tamoxifen treatment cues cell survival signaling activation, implying that modulation of cell survival or apoptosis may be an ancillary molecular target in addition to tamoxifen therapy and warrants further investigation
C., Hiona, A., Pugh, T
doi: 10.3390/ijms22083974
