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Overall, COMT inhibitors and MAOB inhibitors are used in combination with levodopa to prolong its effects and reduce fluctuations, and dopamine agonists can delay the need for levodopa in early disease stages and reduce dyskinesia riskthough they may cause impulse control disorders and hallucinations as side effects [6, 9, 10]

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F.LarrosaN.GomisX.GilabertJ.et al

Normally inhibited by IB, NF-B becomes activated upon 4-HNE-mediated phosphorylation and the degradation of IB, leading to the increased expression of pro-inflammatory cytokines [40,46]

Moretti M, Bottrighi P, Dallari R, Da Porto R, Dolcetti A, Grandi P, Garuti G, Guffanti E, Roversi P, De Gugliemo M, Potena A (2004) EQUALIFE Study Group
