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A phase II study of the HDAC inhibitor givinostat in combination with hydroxyurea in patients with polycythemia vera resistant to hydroxyurea monotherapy

Kurtzberg J, Asselin B, Bernstein M, Buchanan GR, Pollock BH, Camitta BM

Reduce headaches and facial pain caused by nighttime grinding

A 2020 double-blind, placebo-controlled study in Dermatology Practical & Conceptual showed that glutathione significantly improved skin elasticity, reduced wrinkles, and brightened skin tone over the course of 12 weeks

In Parkinsons disease, curcumin inhibits DNMTs, leading to demethylation and reactivation of neuroprotective genes like Nurr1, DJ-1, and PARK genes, and acts as an HDAC inhibitor to enhance histone acetylation, promoting transcription of genes involved in neuronal survival and synaptic plasticity