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Monitor patients closely, and perform serum liver testing prior to therapy and at frequent intervals thereafter (5.1) Fetal Risk, particularly neural tube defects, other major malformations, and decreased IQ (5.2, 5.3, 5.4) Pancreatitis, including fatal hemorrhagic cases (5.5) Indications and Usage for Depakote Pellets Depakote Sprinkle Capsules are an anti-epileptic drug indicated for: Monotherapy and adjunctive therapy of complex partial seizures and simple and complex absence seizures

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Most frequently double bonds in PUFAs are separated by a methyl group (or most correctly methylene group) forming a -C=C-C-C=C- structure which is known as "unconjugated structure", which is the layout of double bonds in most naturally occurring PUFAs [26]