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Multiple studies have shown that the Notch and transforming growth factor-1 (TGF-1)/Smad3 pathways could trigger epithelial-mesenchymal transition (EMT) and extracellular matrix (ECM) accumulation, leading to renal interstitial fibrosis (85)

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doi: 10.1111/1346-8138.14933 61 Olejniczak-StaruchICiyskaMSobolewska-SztychnyDNarbuttJSkibiskaMLesiakA

An improvement in symptoms (urgency and frequency of urination) occurred as early as 2 weeks after the procedure

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