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Notably, these microspheres were observed to be capable of automatic adjustment: they exhibited enhanced degradation in OA joints, and the loading of celecoxib significantly inhibited this degradation

The two major pathways for the degradation of proteins involve the selective elimination through the ubiquitin-proteasome system (UPS) and removal through chaperone-mediated autophagy (CMA) (128)

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The compound demonstrates exceptional target selectivity, with no inhibition of related methyltransferases (DNMT1, PRMT3, COMT) or NAD+ salvage enzymes (NAMPT, SIRT1) at concentrations up to 600 M

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