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In contrast, the administration of curcumin in HepG2 cells treated with the conditioned medium derived from hepatic stellate cells prevents HIF-1 stabilization, suppresses angiogenesis and upregulates GSH through the Nrf2 pathway [310]
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181 These studies show that role of lactate in fatty acid metabolism differs between the TME and normal tissues, suggesting a complexity in its function
As a result, some experts advocate considering creatine supplementation, particularly for athletes at higher risk for repeat concussions
