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fumigatus contains three putative zinc transporter-encoding genes (zrfAC) whose expression is regulated by both pH and the environmental concentration of zinc.8,9 Two of these transporters, coded by genes zrfA and zrfB, are transcribed at higher levels and are required for fungal growth under acidic zinc-limiting conditions, while they are not required for growth in neutral or alkaline zinc-limiting media,286 the conditions found in lung tissues

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These results suggest that CaSR in taste cells is involved in the perception of kokumi substances