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Proponents suggest that these routes may allow for higher bioavailability compared to oral supplementation, though it's important to note that human pharmacokinetics, tissue distribution and durability of NAD+ level changes after injection are not well characterised

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doi: 10.1016/S0305-4179(01)00055-9

"Elamipretide Improves Mitochondrial Function in the Failing Human Heart" Journal of the American College of Cardiology