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10.2 Mechanisms and epidemiology Nociplastic pain stems from central sensitization, involving abnormal pain processing in the peripheral and central nervous systems, leading to increased sensitivity and reduced inhibition

Therefore, the objective of the present study was to investigate how intermittent fasting significantly alters neurotransmitter levels, namely norepinephrine (NE), dopamine (DA), serotonin (5-HT), gamma-aminobutyric acid (GABA), glutamate (GLU), aspartate (ASP) and glycine (GLY), in the brain, the changes in neurotransmitter levels are dependent on the duration of the intermittent fasting regimen, and the effects of intermittent fasting on neurotransmitter levels vary across different brain regions

doi: 10.1517/17425255.2011.577738

Most excluded studies focused on specific dermatological conditions (acne, psoriasis, radiotherapy-induced dermatitis) rather than addressing general skin health and age-related changes