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Its deficiency results in reduced NAD + synthesis and accumulation of its substrate, NAM, leading to increased NNMT activity and further decline in NAD + levels
10.1002/ptr.7992 62 ZhaoT.LiuJ.ZengX.WangW.LiS.ZangT.et al (2021)
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Plant Cell Tiss
Usual abnormalities in WD brain MRI include symmetric hyperintense changes visualised in T2-weighted images located in basal ganglia (mainly putamen and caudate nuclei), thalami, midbrain, and pons 94,114,120123 (Figure 7)
