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People concerned about muscle loss during GLP-1 therapy may find the combination appealing

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The US-FDA initially approved the drug in 1942 (7)

Beyond Fat Loss: Cartilage and Joint Health Data A 2015 rabbit osteoarthritis model found that intra-articular injection of AOD-9604 at 0.25 mg weekly over 47 weeks enhanced cartilage regeneration, with greater effect when combined with hyaluronic acid