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Clinical translation requires human CSF pharmacokinetic assays to prove BBB bypass, a rigorous dose-escalation Phase I trial to establish a safe human NOAEL for chronic dosing, and an RCT utilizing precise neurocognitive testing (e.g., MoCA) to confirm that murine transcriptomic shifts yield functional neuroprotection in humans
Probiotic supplementation and microbiome restoration offer new insights into the treatment of vaginal candidiasis (Valentine et al., 2025)
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Autophagy markers also showed significant positive correlations with MAD and inflammatory cytokines such as TNF- and TGF-3 [11]
Endocrine disrupting chemicals and disease susceptibility
