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PD-1 inhibition in cancer patients has been linked to the gut microbiota, including Faecalibacterium, Bifidobacterium, and Akkermansia, according to several studies (Wu et al., 2009), direct DNA damage (Tsoi et al., 2017)
Timing is another important aspect of any study design
FASEB J (2015) 29(12):476671
M., Pickett L
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