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OCT2 in particular contributes significantly to accumulation of oxaliplatin, and genetic or pharmacological knockout of OCT2 prevented the development of cold and mechanical hypersensitivity following treatment with oxaliplatin, suggesting that the OCT2 transporter plays a crucial role in oxaliplatin-induced cytotoxicity (Sprowl et al., 2013)

Once activated, these microglia release neurotoxic substances that further damage neuronal synapses and disrupt the synthesis of vital neurotransmitters like acetylcholine, dopamine, and serotonin

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Vitamin C (as Ascorbic Acid), L -Glutathione, Coenzyme Q10 (CoQ10)

Often detected incidentally during dilated retinal examination