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That depends on what you are trying to accomplish, what your labs and history look like, and what else you are taking

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Milk thistle (silymarin, the active compound in milk thistle) has been used for centuries for liver support, Multiple randomized controlled trials and systematic reviews have examined silymarin for hepatoprotective effects in humans with liver disease and toxin-related liver injury

Thus, therapies like prolotherapy or PRP injections in a vEDS patient must be approached with extreme caution or generally avoided unless absolutely necessary, and only with expert oversight

After the medication is delivered, remove the needle in one smooth motion and apply gentle pressure with gauze if needed