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Specifically, the PTEN-induced kinase 1 (PINK1)/Parkin pathway is a classic mechanism that activates mitophagy by mediating the recognition of damaged mitochondria

suggests several methodological strengths, including a controlled experimental design with multiple intervention arms (vitamin D, swimming exercise, and their combination), baseline equivalence between groups, and the assessment of both physiological outcomes and mechanistic biomarkers such as FATP4 and TLR4 expression

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