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Description
The peptide achieves these complex neurological stabilizations largely through intricate, bidirectional interactions with the nitric oxide (NO) system, dynamically responding to both NO-system blockade (via L-NAME administration) and NO-system over-stimulation (via L-arginine administration) to restore neurological homeostasis

Therefore, intranasal administration of chitosan-modified nanoemulsions resulted in a higher drug concentration in the brain than administration of the free drug solution and positively affected in-vivo neurobehaviors

Starting at 0.5% to 1% provides a reasonable baseline that delivers meaningful effects while maintaining safety margins

Wissenschaftliche Quellen & Referenzen: FDA (U.S

doi: 10.1016/j.dnarep.2015.04.002 188 LinY-LLiY
