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GBM-EVs were internalized by reactive astrocytes and appeared to reprogram astrocyte metabolism by delivering mRNAs for glycolytic enzymes (enolase 1, hexokinase-1, and hexokinase-2) and oxidative phosphorylation (cytochrome c oxidase) to activate the biosynthetic processes needed for tumor growth [150]

PMC 11228880

Generally safe

Mtorc2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT

This paradigm shift has unveiled critical limitations in current antioxidant approaches while simultaneously opening unprecedented opportunities for mechanism-targeted interventions