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The loss of motor and sensory function, along with chronic pain caused by sciatic nerve injury, significantly impacts patients quality of life

Thus, the mechanisms of MNP action have a reproducible architecture across different organs but with organ-specific accents: impaired barrier functions and neuroinflammation in the CNS, hormonal dysregulation and transgenerational effects in reproduction, fibrosis and mitochondrial dysfunction in the heart and kidneys, and microbiota and metabolic disruption in the digestive tract and liver

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Furthermore, it was discovered that indenopyrazole, without any impact on HIF-1 protein synthesis or heterodimerization, significantly reduced the transcriptional activity of HIF-1 [81,110]