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Investigated in vitro for selective clearance of senescent cells

Ochoa, University of Granada, Spain Reviewed by Andrea Alvarez-Sala, University of Valencia, Spain

In senescent cells, FOXO4 holds p53 in place and stops it from starting apoptosis, which is the process of programmed cell death

20 Therefore, considering the anatomical, physiological and pathological characteristics of the lung, the size, shape, surface properties and aerodynamic characteristics of nano-/micron-sized particle carriers determine the deposition and bioavailability of the drug in the lung

Purification of recombinant Lyn 293T cells expressing recombinant His-tagged Lyn were lysed in cold NP-40 lysis buffer and incubated on ice for 30 min