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Procognitive and neuroprotective activity of a novel alpha7 nicotinic acetylcholine receptor agonist for treatment of neurodegenerative and cognitive disorders

Free carnitine directly facilitates mitochondrial fatty acid uptake and -oxidation [31], Acylcarnitines are esters formed by conjugation of free carnitine with fatty acyl groups of varying chain length, and are categorized as short-chain ( C6, e.g., acetylcarnitine C2, propionylcarnitine C3), medium-chain (C7-C12, e.g., octanoylcarnitine C8, decanoylcarnitine C10), and long-chain ( C13, e.g., palmitoylcarnitine C16, stearoylcarnitine C18) derivatives [32,33,34]

The reaction, a substrate-level phosphorylation, is the first of two reactions in the glycolytic pathway in which part of the chemical energy contained in glucose is conserved in the form of ATP

10.1055/s-0034-1368720 94 RojeB.ZhangB.MastrorilliE.KovaiA.SuakL.LjubenkovI.et al

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